Amino Acids, Peptides and Proteins (SPR Amino Acids, by John S. Davies

By John S. Davies

This product isn't really to be had individually, it's only offered as a part of a collection. There are 750 items within the set and those are all offered as one entity. summary: This product isn't really to be had individually, it is just bought as a part of a collection. There are 750 items within the set and those are all bought as one entity

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Additional resources for Amino Acids, Peptides and Proteins (SPR Amino Acids, Peptides, and Proteins (RSC)) (Vol 35)

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A-Alkyl-aphenylglycines were obtained365 by asymmetric synthesis, via phenylation/ alkylation of (2R, 3S)-N-Boc-6-oxo-2, 3-diphenylmorpholine followed by hydrolytic ring opening. a-Arylation in high yields has been reported366 for the reaction of aryl bromides with protected glycinate esters in the presence of Li or Na hexamethyldisilazide and Pd(dba)2/ligand. ArCOHN R2 R N N NH2 CO2H O (64) R2 1 CO2H R (65) R3 R H 2N N R CO2H (66) Amino Acids, Pept. Proteins, 2006, 35, 1–73 29 Fmoc-L-p-Azidotetrafluorophenylalanine has been prepared367 from acetamidomalonate, followed by enzymic resolution.

Iodine powder/hydrogen peroxide mixtures have furnished108 L-thyroxine from L-tyrosine. Non-proteinogenic amino acids now encompass a wide range of structures and are sometimes difficult to retrieve from the literature as they are often referred to only by their ‘trivial’ name. However statines, due to their pharmacological importance, are well-documented. 109 Both the anti and syn forms were obtained from precursor b-ketoesters via reduction and aldol reactions. Both enantiomers of statine (18, R1¼Bui, R2¼H, R3¼H, without Boc) have been synthesised110 by exploiting an a-lithiated alkyl sulfoxide as a chiral ahydroxyalkyl carbanion equivalent, while another method111 utilised orthogonally protected syn-2-amino-1, 3, 4-butantriol as a general syn-aminoalcohol building block.

98 The partially hydrogenated aromatic ring of phenylalanine (1,4dihydro-L-phenylalanine), produced as a minor product in the Birch reduction of the amino acid, has been shown99 to be a moderate competitive inhibitor of phenylalanine ammonia lyase rather than a substrate. In an enzyme-assisted100 preparation of D-tert-leucine, it was (Æ)-N-acetyl-tert-leucine chloroethyl ester that exhibited the highest rate of hydrolysis. Amino acid anhydride hydrochlorides have been used101 for the first time as acylating agents in Friedel-Crafts reactions, resulting in the synthesis of Lhomophenylalanine from aspartic acid.

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